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Bivariate and multivariable logistic regression was performed to compare MDR and XDR cases to susceptible cases (SPSS 13.0).
The group of susceptible controls was collected by combining the entire population of susceptible cases from 2002 2006 with the randomly selected susceptible group from 2007.
The 117 Susceptible cases were 20.5% females (24/117), with a mean age of 42 years (SD 14.5) (see Table 1).
The possibility that drug resistance evolved rapidly in drug susceptible cases receiving optimal treatment appears less likely based on clinical history and collateral information regarding adherence obtained from tuberculosis clinics and relatives.
Larger studies in Latvia and Donetsk Oblast have suggested an association between HIV and MDR-TB, [10] and in the United States, HIV was significantly more common among XDR cases as compared to drug susceptible cases.[24] With an overall HIV prevalence of less than 1%, India may not yet have enough HIV cases to experience a significant overlap between the HIV and drug resistant TB epidemics.
We hypothesize that harvesting of susceptible cases reflects the causal mechanism of stone formation and explains the short lag between hot days and stone presentation.
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"If the public health system and medical community are able to identify every single susceptible case and get them into isolation, we have a chance of stopping this outbreak here".
We did not address imidacloprid exposure from food or from residential proximity to commercial spraying, nor did we distinguish genetically susceptible case subgroups, who may have different associations with environmental exposures.
Rhabdomyolysis-susceptible cases performed better from standstill starts (p = 0.04) than controls and had a higher percentage of wins (p = 0.006).
In other sets of runs, the protective effect is set to other values (75% and 50%) so that contact between active-MDR cases and drug-susceptible cases can result in MDR-infection albeit at a reduced rate.
Boldface indicates significant difference in statistical comparison of baseline characteristics in the corresponding drug-resistance group to drug-susceptible cases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com