The second major lineage was found to be a novel sequence type (designated as ST1559), of which all 19 were carbapenem susceptible (variable susceptibility was observed against the other seven antimicrobials tested) (Fig 1C).
The gentamicin susceptibility of P. aeruginosa ranged from 44.0% in France to 74.0% in Germany, whereas Acinetobacter spp. showed more variable gentamicin susceptibility varying from 23.3% in Italy to 82.0% in Germany.
Additionally, genetic variability plays a critical role in individual susceptibility because variable detoxifier phenotypes result from mutations in the same gene.
Genetic and epigenetic variants combine to influence observed differences in disease susceptibility and variable disease progression.
Advances in genomic technology and computational approaches have significantly changed our understanding of the non-random distribution of human genetic variants and its impact on disease susceptibility and variable drug response across human populations.
Susceptibility is variable between individuals depending on endo- and exogenous risk factors, such as essential hypertension, salt sensitivity, old age, malnutrition, use of diuretics, chronic inflammatory conditions and mutations in the 11-beta-HDS2 gene.
Since the diagnosis of AS poses some specific difficulties because of proteinase K susceptibility and variable distribution of PrPRes [ 4], EFSA also evaluated the sensitivity of the different TSE rapid tests to detect AS on different biological material (table 1) [ 5, 6].
Variable-temperature (2.0 300 K) dc magnetic susceptibility and variable-field (0 5.0 T) magnetization measurements on these two series of compounds reveal a distinct magnetic behavior mainly depending on the diamagnetic or paramagnetic nature of the LiI and MnII ions, respectively.
This study aimed to appraise the adaptation to biofilm mode of growth of I. limosus and D. pigrum and determine their respective antibiotic susceptibilities in variable-oxygen atmospheres resembling CF airways.
Escherichia coli showed variable susceptibility to the tested antimicrobials with 40.0% susceptible to Ampicillin, Chloramphenicol and Cotrimoxazole; 20.0% susceptible to Tetracycline; and 80.0% susceptible to Gentamicin and Cefuroxime.
