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This suggests that in this line of rabbits, some have developed susceptibility to development of autoantibodies regardless of the immunogen.
Slc6a6 knock out mouse models demonstrate a phenotype of dilated cardiomyopathy with cardiac atrophy [36], lower fasting blood glucose, acceleration of glycolysis in skeletal muscle and susceptibility to development of obesity when placed on a high fat diet [37].
Feeding lactating dairy cows dried distillers grains with solubles (DDGS) increases the concentration of unsaturated fatty acids in the milk from those cows, potentially leading to increased susceptibility to development of off-flavors.
In this review, we summarize the evidence for a genetic susceptibility to development of sepsis and death from sepsis, discuss design of clinical genetics studies relevant to the study of complex disorders, consider the candidate genes likely to be involved in the pathogenesis of sepsis, and discuss the potential for targeted therapy of sepsis and septic shock based on genetic variability.
For example, progression of LTBI to active disease can occur following TNF-α blocking treatments for chronic inflammatory diseases [5], while genetic defects involving IL-12 (as for IFN-γ [9]) increase susceptibility to development of active TB disease [6].
The hygiene hypothesis suggests that a lack of microbial exposures during the crucial stages of immune maturation in infancy, results in immune modulation (Th2-biased response) that increases susceptibility to development of allergic disease [17].
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In summary, we have shown that aging per sedoes not contribute to the development of NAFLD; however, it does increase susceptibility to the development of diet-induced NAFLD.
This suggests that deregulation of JAK2 signaling via effects on SOCS can contribute to RA development and may predict a patient's susceptibility to disease development.
The HLA system involvement in the development of cancer is poorly understood; nonetheless, it is widely recognized that MHC genetic variations lead to greater susceptibility to neoplasm development [ 9].
Our findings suggested that the susceptibility to the development of MA differs according to sex and age in patients with cardiac shunt.
Therefore, it follows that reconstruction of the digestive tract increases the susceptibility to the development of hyperglycemia, which is a risk factor of disease onset.
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