An international consortium undertaking a genome-wide linkage analysis in breast cancer families lacking BRCA1/ BRCA2 mutations identified one large family in which a complex pattern of inheritance of cancer susceptibility pointed to the hCHK2 gene on chromosome 22.
On the other hand, the determination of resistance based on a susceptibility break point level alone [ 12, 13] irrespective of the resistant breakpoint level might have led the classification of isolates that displayed an intermediate resistance phenotype in the resistant category.
Differential susceptibility theory points to the role of the individual characteristics in moderating not only the effects of stressful environmental conditions but also of supportive contexts, on human development.
Susceptibility break points to various antibiotics tested, were taken as per NCCLS definitions [ 12].
For facilitation of clinical decision making and surveillance, azithromycin susceptibility break points for Enterobacteriaceae should be standardized (12 ).
Recently, on the basis of the integration of epidemiologic, molecular, and limited clinical data, the Clinical Laboratory Standards Institute (CLSI) updated antifungal susceptibility break points for Candida spp. (10, 11 ).
For clindamycin (MIC, ≤2 mg/L), gentamicin (MIC, ≤2 mg/L) and meropenem (MIC, ≤4 mg/L) the susceptibility break points of the National Antimicrobial Resistance Monitoring System NARMSS) were used [ 23, 24].
Antibiograms were created by using the disk-diffusion method on Mueller-Hinton agar (Bio-Rad Laboratories, Marnes-La-Coquette, Frande), and susceptibility break points were determined as previously described and interpreted as recommended by the Clinical and Laboratory Standards Institute (22, 26 ).
In cases in which no organisms are isolated, the susceptibility break point of the least susceptible potential pathogen should be used [99, 103].
In cases in which no organisms are isolated, the susceptibility break point of the least susceptible potential pathogen should be used [ 99, 103].
