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This is completely opposite to our original hypothesis, in which we thought that the susceptibility determinants of MMTS action were localized in the interface.
8– 12 However, these studies have identified only 23% of the susceptibility determinants for Crohn's disease (CD) and 16% for ulcerative colitis (UC).
The primary goal of the GARP study is the identification of genetic susceptibility determinants to OA and disease progression in middle-aged sibling pairs with OA at multiple joint sites.
For instance, it is reasonable to consider that autoimmune diabetes development is impacted most significantly by HLA risk alleles (Wong et al., 2004; Stadinski et al., 2010), and to a lesser degree by other susceptibility determinants including potentially compromised Treg cells.
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The authors suggest that variation in the CPR gene may be a primary susceptibility determinant in paraquat toxicity.
Additionally, our results clearly identified the HLA-Bw4 epitope with isoleucine at position 80 as a possible major genetic susceptibility determinant of BD in Germans.
Gender-specific factors, whether risk activities or host-susceptibility determinants, may have contributed to acquiring SPHS because women who with leptospirosis had twice the risk for this disease form.
There are likely multiple additional COPD susceptibility genetic determinants that have not yet been identified.
Although some of these sex differences have been in part attributed to biological susceptibility, social determinants of health and other factors, these gaps have not been fully explained in the current literature.
The present study aimed to investigate antimicrobial susceptibility, genetic resistance determinants focussing on extended-spectrum cephalosporins and ciprofloxacin, and the molecular epidemiology of N. gonorrhoeae strains that were circulating in India, Pakistan, and Bhutan in 2007 2011.
We are currently testing this hypothesis by evaluating these phenotypes in a panel of unique congenic rat strains that were developed to characterize the QTL that were identified as genetic determinants of susceptibility to E2-induced mammary cancer in intercrosses between susceptible ACI and resistant BN rats [ 22, 23].
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