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Cytokine polymorphisms are among the most important genetic factors influencing an individual's susceptibility and development of the disease.
With changing patterns of microbial disease epidemiology, re-emergence of certain infectious diseases, antibiotic susceptibility, and development of superbugs, a systematic reappraisal of EE is necessary.
They have generally been considered to contribute to mucosal health; however, it is logical that these AMPs are biological factors that influence caries susceptibility and development as well.
The causes of LOAD are complex and not yet fully understood, but there is evidence that genetics plays a strong role in Alzheimer's susceptibility and development.
One weakness of this study is that we did not investigate how rs2229238 C/T was functionally involved in the susceptibility and development of TB.
Anyway, future studies will be needed to clarify any role played by R. norvegicus in VL transmission, especially regarding susceptibility and development of Le. infantum infection at different life cycle stages of that rodent species.
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Intense and ongoing research efforts into the genetics of SLE have greatly advanced our understanding of the susceptibility to and development of the disease [ 1, 2].
Impressive progress has been made in the analysis and interpretation of genomic data sets, the identification of novel mechanisms of breast cancer susceptibility, growth and development and the parallel integration of these molecular data to test novel therapeutic approaches for patients with this disease within clinical trials.
The advent of high-throughput, whole-genome DNA sequencing has enabled the evaluation of normal and tumor tissue samples from hundreds of patients in a single study, revealing both germline and somatic mutations with potential involvement in cancer susceptibility, initiation and development.
Genetic effects have long been suspected to play a role in the initial susceptibility and subsequent development of severe C. albicans infection in humans[7] and in animal models of experimental infections[8], [9].
Genetic association of KD with inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in a genome wide scan has been recently reported by Onouchi et al. They first indicated a functional SNP in the ITPKC gene associated with KD susceptibility and the development of coronary artery lesions [9].
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