Both in survivors and non-survivors, the proportion of patients with bilirubin level above the ULN increased mildly at T-ASTmax and then gradually decreased again.
All the more, for some groups of CRC survivors, the proportion of HLE exceeds that of the general population, highlighting the importance of early detection.
Survival, i.e. the proportion survivors of the 1965 mature population (surviving+dead) per site, was modelled with a quasibinomial error structure (to allow for overdispersion) and a logit link.
Kaplan-Meier estimates for the number at risk of death, the number of deaths and proportion survivors, aggregated into 2-day time intervals up to 20 days, and two 5-day intervals up to 30 days, are provided in online supplementary appendix A1.
When hospital mortality was analyzed, only ISC IgGAM showed differences for the proportion of survivors and non-survivors between patients with low and high immunoglobulin levels (Table 4).
Evolution of the proportion of survivors and non-survivors with alkaline phosphatase (left) and bilirubin (right) levels within and outside the reference range.
Among families with at least two survivors there was a negative relationship between proportion of survivors and the overall parasite load averaged over family (Fig. 3, weighted least square regression, R2 = 0.674, F1,7 = 14.442, P = 0.007), which could together with the negative correlation to growth rate reflect the increased fitness cost in families with higher average parasite loads.
Long-term objectives associated with cancer survivors have been suggested by Healthy People 2020, including increasing the proportion of survivors living beyond 5 years after diagnosis and improving survivors' mental and physical health-related quality of life.
In addition to coping support, valuable insight about how to prevent or address survivors' unmet needs could be gained by examining the substantial proportion of survivors who report no unmet needs.
When considering the interaction of survivors with the health service, a person-time approach has a distinct advantage, as it allows us to estimate the proportion of survivor time spent admitted to hospital, as well as to count the number of admissions.
