Sentence examples for surviving progenitors from inspiring English sources

This allowed for an assessment of the effect of STI571 on surviving progenitors following culture in suspension.

These ectopic Crz-ir neurons, henceforth referred to as vCrz-sib, are most likely derived from their surviving progenitors (EW3-sib) that normally undergo apoptosis during embryogenesis (Novotny et al., 2002; Lundell et al., 2003).

It is quite possible that the surviving neural progenitor cells behave similarly to the breast tumor cells or breast cancer progenitor cells (BCPCs) in that prevention of ceramide-induced apoptosis promotes survival and proliferation of the progenitor cells.

This includes: (1) protecting cells of glial origin from cell death, (2) stimulating massive cell death of neuronal progenitor cells as induced by glutamate, and (3) stimulating extensive neuronal differentiation of the surviving neuronal progenitor cells.

Knockdown of hif2α, birc5a or birc5b reduced the expression of the cdk inhibitors p27/ cdkn1b and p57/ cdkn1c and increased ccnd1/ cyclin D1 transcription in the surviving neural progenitor cells.

The reduction in elavl3/ HuC expression and enhanced pcna, nestin, ascl1b and sox3 expression indicate that the surviving neural progenitor cells in hif2α morphants maintain a high proliferation rate without terminally differentiating.

However, surviving epidermal IC progenitors in foxi3a morphants are blocked in an undifferentiated status and lose the expression of the differentiating markers of ndrg1, kcnj1, atp1a1a.2, arg2, trpm7, and atp6v0c (Figure S5).

On the other hand, we speculate that this pattern may also reflect the peculiar scenario of the neonatal brain, in which we showed random loss of transduced cells in the few days following LV transduction, coupled to moderate and physiological expansion of the subset of surviving vector-marked progenitor cells.

Monje et al. [10] have demonstrated that normal number of neural progenitors was surviving two months after radiation exposure although proliferative activity was reduced.

DOI: http://dx.doi.org/10.7554/eLife.00966.013 Following this pattern of stochastic fate choice, previous studies have shown that the size distribution of clones derived from a single progenitor cell converge onto a scaling form in which the chance of finding a surviving clone with n>0 progenitor cells after a time t post-labelling is given by, P n surv.

To further characterise the effects of STI571 on PSCs, the clonogenicity of the surviving fraction of committed progenitor cells were analysed in colony-forming assays.