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As described in the Methods, survival rates of APP695-expressing progeny were calculated as a percentage of surviving control progeny that were obtained from the same genetic cross (see Greeve et al., 2004).
Survival rates of APP695-expressing progeny were calculated as a percentage of surviving control progeny (lacking the promoter constructs) that were obtained from the same genetic cross, and therefore were raised under identical conditions [as previously described (Greeve et al., 2004)].
Following challenge, both the vaccinated and surviving control mice presented VN antibodies on day 23 post-infection (data not shown).
Following 12 weeks of reconstitution of the secondary hosts, the surviving recipients of Gab2−/−STAT5abnull/null BM were analyzed for donor chimerism along with all of the surviving control mice from the other three groups (Fig. 7B).
Fig. S5 shows the surviving control mice on day 307 compared with four representative MP-MUS treated animals.
It was not feasible to follow the surviving patients further as advance care planning was subsequently provided to the surviving control patients.
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The three surviving controls all developed VP7-specific antibodies by day 23 post-infection, indicating the animals immune system responded to the antigenic exposure.
Twenty three of 25 (92%) surviving cases and 70/76 922%) surviving controls had neurodevelopmental assessments completed.
Sixteen (27%) of the surviving cases and 4 (2.6%) of the surviving controls who were judged non-demented at admission were demented three months after admission.
Three months after neuroleptic use 27% of the surviving cases and 2.6% of the surviving controls who were judged non-demented at admission were identified as demented.
Of the 104 surviving infants (27 cases, 77 controls), there were 3 infants who were lost to follow-up, resulting in a total of 25/27 933%) surviving cases and 76/77 999%) surviving controls that had long-term follow-up.
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