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Notably, loss or functional inactivation of the cognate receptor often enables tumor cells in vivo to overcome the growth inhibitory effect of TGFβ early in tumorigenesis, however, during metastatic progression, autocrine TGFβ appears to play a tumor-promoting role, possibly enabling tumor cells to survive significant changes in microenvironment [ 23].
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Each species is so well coordinated, functionally and structurally, that it could not survive significant change.
A proof-of-concept experiment showed that the battery with modified electrodes survived significant mechanical deformation without any change in the open-circuit voltage of the battery.
This new arrangement survived with few significant changes for the rest of the 20th century.
In those who survived there are significant changes during the first 48 h in the GH/IGF-I axis, suggesting a decrease in the GH resistance.
"The textile industry in Connecticut peaked in the middle of the 20th century and, to survive, the companies remaining have had to make significant changes in their operations," said Peter Gioia, an economist with the Connecticut Business and Industry Association in Hartford.
Gage survived the accident, but those who knew him reported significant changes in his personality and behaviour.
If patients survived longer than 6 months, Blessed or nursing staff repeated the test and recorded any significant changes (Blessed interview, 2013).
And significant changes to her policy platform are likely if she survives.
In the biofilm state, bacteria undergo significant changes in gene expression leading to phenotypic changes that serve to enhance their ability to survive in challenging environments.
These are significant changes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com