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20 21 The function of autophagy activation in these mice, as with the human SLE data, may represent an attempt by autoreactive B cells to survive deletion.
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While this would limit the number of detectable events compared to FACS, it could complement the FACS data and report the number of viable cells that survive deletions.
Those were, by the way, the parts of her rant that survived deletion.
Similarly to the findings on HSCs, quiescence is still protective for hair follicle bulge stem cells since resting cells survive ATR deletion whereas cycling cells suffer p53-mediated deletion (Ruzankina et al., 2009).
Furthermore, supraphysiological concentrations of myelin antigens associated with PLP-overexpression could promote reactivity of low-avidity T-cell clones that survived clonal deletion or ignorance in the thymus [4].
Thirty-two itemsurviveded the deletion algorithm.
After polypolidization, duplicated genes encoding interacting proteins that are dosage sensitive tend to survive together because deletion of one copy would mimic an aneuploid effect.
It also induces chromosomal aberrations and some HSCs survive with a deletion of chromosome 2, being hemizygous for the Sfpi1 gene.
The finding that clones of missense mutants in the eye rarely survive while clones of deletion mutants develop normally further supports this notion.
We discovered that to better survive from the random deletion process, persistent genes, which are under inherent high purifying selection pressure, organized as clusters.
These data fit a model in which a pre-existing partial genome duplication can predispose a small proportion of the parasite population to survive integration of a deletion vector for an essential gene.
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