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The frequency of AhR −/− ILC3s is still normal at early time point after birth, but the AhR −/− ILC3s are not able to survive consistent with reduced c-kit expression in such cells.
Interestingly, in our initial experiments we found that that HeLa cells transfected with KChIP3 but not KChIPs 1, 2 and 4 failed to survive, consistent with distinct physiological effects of these proteins.
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The number of animals that survived is consistent with our previous reports.
The increase in bcl-2 seen in patients who survived is consistent with a protective role for this anti-apoptotic protein after TBI.
The levels of the cytotoxic factors perforin and Gym A and B were elevated in the brains of dying mice relative to surviving mice, consistent with the elevation of Treg-related genes.
Furthermore, we also found that patients with low TS activity and high OPRT activity survived longer, consistent with studies that have reported TS activity to be a good parameter by which to predict postoperative survival and to evaluate the effectiveness of 5-FU[ 16, 17].
Approximately 10% of the Insm1 homozygous null pups survived to E18.5, consistent with the results of Gierl et al. (Gierl et al., 2006), with all other embryos dying between E15.5 and E18.5.
Treatment with 500 μM verapamil resulted in 100% lethality (none of the animals survived to adulthood), consistent with the adverse effects of higher verapamil concentrations in the MC65 cultures (see Fig. 3).
The fact that a small population of these breast cancer stem-like cells survives chemotherapy is consistent with the notion that the surviving tumorigenic cells are responsible for the 40% recurrence rate of invasive breast cancer.
Specifically, ankyrin-B+/− mice live on average to ∼90 weeks; while their wild-type littermates survive to ∼120 weeks (consistent with the C57Bl6 life-span [34]).
A correlation between a defective purine nucleotide salvage pathway and reduced ability of B. ovis to survive intracellularly would be consistent with the importance of purine biosynthetic pathways for full virulence of B. abortus and B. melitensis [51], [52].
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