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The 'short' survival was derived from Ugandan subjects[12], 'medium' survival from Western subjects[13] and the 'long' survival from the a collaborative study sites (mainly from sub-Saharan Africa).[14] The shape and scale of these three curves differed, therefore generating a range of incidence curves G s)(Appendix S1).
Expected survival was derived from the Malaysian life tables.
For the first two periods, 3-year survival was derived from a cohort design.
Progression-free survival was derived based on tumor assessments by the investigators.
Using the so-called Ederer II method [ 28], expected survival was derived from life tables for the year 2000.
Besides crude survival, age standardized survival was derived as weighted average of age group-specific survival based on weights from the International Cancer Survival Standards (ICSS) [ 33].
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Data for expected survival were derived from population life tables.
The rarity of this disease means that most information regarding survival is derived from these clinical trials.
Estimates of relative survival (calculated as the ratio of observed and expected survival) were derived using the so-called Ederer II method (Ederer and Heise, 1959) and life tables for the year 2000.
In this study, gene expression biomarkers of relapse-free survival were derived from the gene expression profiles at three different time points on samples of 73 patients with B-ALL (55 children and 18 adults).
The survival curve was derived from the cumulative survival rate over time.
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