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Non-CRC patients were willing to repeat therapy for smaller survival thresholds than CRC patients.
In contrast, patients in our study were asked to state the exact survival thresholds for which they would repeat chemotherapy.
In the current study, patients' anticipated median survival thresholds were longer (CRC 36.0 months; non-CRC 18.0 months) than described in previous reports [ 7- 11].
As in several other trials, gender [ 9- 12] as well as previous therapy experience [ 12] did not influence the anticipated survival thresholds.
Binder et al. [ 30] applied three different survival thresholds to evaluate a binary classifier based on gene expression, and showed how the choice of threshold affected the predictions.
After adding the median survival time with best supportive care to the patients' stated survival thresholds, this expected survival was plotted against the patients' actual survival as shown in Figure 3.
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If the nutrition is below a survival threshold T survive, the individual dies, resulting in an outcome of 0 to signify no progeny.
We found that recovery was significantly less than expected in the animals with nadir CD4 preservation below the survival threshold.
The horizontal dashed line in Figure 3A is the survival threshold for the chronic preservation of 24.1% of CD4+ T cells from the diagnostic test.
The grey area encloses CD4+ T cell levels in the acute phase lower than the survival threshold, as determined by the ROC analysis.
The metabolic reference point is often taken in ecology as the intake rate required to reach a survival threshold, with the increasing probability of starvation as current intake rate drops below threshold promoting risk-seeking behaviour.
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