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The majority of in vivo studies of MSC therapies utilize allogeneic or syngeneic (genetically similar) donor cells because of the difficulty of extracting cells in a survival surgery in small animals.
I wondered, trying to imagine handling a baby's survival, surgery, and moving countries all at once.
However, considering the poor expected survival, surgery may not be a valuable addition.
Procedures were performed in a sterile manner in a room reserved for aseptic survival surgery.
Animals subjected to survival surgery to resect the primary tumor were divided into two cohorts.
Unless otherwise stated, primary tumors were resected in survival surgery performed 4 weeks postinoculation.
Similar(42)
For all survival surgeries carprofen analgesic was also employed.
Mice received survival surgeries when tumors reached approximately 490 mm3 (± 95).
Survival surgeries were again performed and skin invasion examined.
For adult mouse survival surgeries, mice were anesthetized by intraperitoneal injection of sodium pentobarbital.
Twelve trials plus an individual patient meta-analysis (7334 patients) were gathered; the trials were designed to determine if cisplatin- or carboplatin-based chemotherapy improves survival over surgery.
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