Lehman Brothers, the ailing Wall Street bank, is working toward a radical solution in its fight for survival: Splitting itself into a "good" bank and a "bad" one.
When a single train had no appreciable effect on cell survival, splitting it in fractions had no additional effect.
Then, we applied the models to the remaining training datasets and identified the maximum number of probe sets that could also generate a significant survival splits in all remaining training datasets.
Statistical significance of the survival splits was assessed by the log-rank test and a permutation statistic was calculated by randomly reassigning the survival data among cases, repeating the entire survival risk prediction 100 times and estimating how many times the log-rank statistic is lower than the log-rank statistic for the real data.
Case selection [ n = 264]: survival: PFS, split patients by median; restrictions: FIGO II, III, IV; histology: serous; debulk: suboptimal; chemotherapy: contains platinum.
To test the idea that bacteria in the soil cause this reduction in survival, we split broods laid near an Aged carcass and surface-sterilized one half with an antimicrobial solution while leaving the other half unsterilized.
However, when compared with the untreated group, the overall survival in split-dose group was still significantly prolonged (5.2 versus 1.5 months).
AV prophylaxis exposure was treated as a time-varying covariate, and for each contact, survival time was split into pre-AV and AV prophylaxis periods.
Consequently, survival records are split into so called "elementary records" internally, each covering only the time span from a change in any covariate to the next.
Tumour marker LDH was the principal determinant of 5-year survival, making a split between good LDH (N=2036) and intermediate/poor LDH (N=1012).
