Given that three of the 10 largest earthquakes ever recorded have been in Chile, the populace is long accustomed to earthquake survival protocols.
The time problem may be solved by freezing the blastocysts, relying on efficient vitrification and thaw-survival protocols, and transferring them later in a natural cycle.
Although the impact of the survival surgery protocol in the TNBS-treated group was not controlled for in the healthy control group in our study, other studies using the same established surgery protocol and sham treatment revealed a minimal impact of the procedure in itself on these animals [ 25, 27, 29, 30].
Both studies demonstrated better survival with the protocol despite no difference in 24-hour FFP transfusion before and after protocol implementation and despite FFP RBC ratios other than 1 1.
With this protocol, survival rates were 89% for patients with ventricular septal defects, 67% for those with atrioventricular canal defects, and 85% for those with total anomalous pulmonary-venous connection.
Two independent reviewers selected the studies, extracted data using a standardized form, and assessed the risk of bias using the Newcastle-Ottawa scale and a checklist of key methodological elements (for example, use of massive transfusion protocol, survival bias).
After implementation of the standardised treatment protocol, survival improved from 31%to56%6% in the interventional period, 56% of the patients showed a favourable neurologic outcome (26% in the control period) at hospital discharge and were still alive after 1 year.
After blinded review of data from the first 443 patients, the data and safety monitoring board recommended discontinuation of enrollment of asystolic patients because of low survival, and the protocol was amended.
On the other hand, censoring these children in the per protocol survival analysis may have removed a group with low mortality from groups B and C and therefore enhanced the estimated beneficial effect of group A between 9 and 36 months of age.
> -wrap-foot> Adapted with permission from Masuda et al. [ 24] CI confidence interval, ERIRC expert radiologic images review committee, FAS full analysis set, NR not reached, OS overall survival, PPS per protocol set, TTF time to treatment failure, TTP time to progression aMedian Additional secondary efficacy analyses demonstrated no significant differences between treatment groups.
