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This controls growth and survival pathways in cells.
The Nrf2 Keap1 signaling pathway is one of the most important cell defense and survival pathways.
Although many survival pathways are upregulated in CML, they are also active in normal stem cells.
Further, the propargyl moiety of l-deprenyl was found to have neuroprotective effects, up-regulating cell survival pathways [101, 102].
Genetic changes in cell-cycle, apoptotic, and survival pathways cause tumorigenesis, leading to significant phenotypic changes in transformed cells.
Targeting proliferative and survival pathways provides a rationale for drug design and development for hormone refractory prostate cancer.
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Several pro- and anti-survival pathways were altered.
Second, nutraceuticals can downregulate tumor cell-survival pathways.
Apoptosis can be modulated by targeting pro-apoptotic or pro-survival pathways.
Importantly, Akt activates other pro-survival pathways.
SRC is an important kinase regulating cell-survival pathways [ 75].
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