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Stories of survival Members of the UN mission joined in distributing bags of food supplies to people who eagerly queued up at local relief centres.
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In addition to their role in normal biology, pro-survival members of the BCL-2 protein family have been identified as critical primary or secondary oncogenic events during tumorigenesis.
Evaluation of the effects of loss of TIEG1 on Bcl2 family members revealed no elevation of pro-survival members including Bcl2 and no suppression of pro-apoptosis family members (Table S2).
Intrinsic apoptosis is mediated by the Bcl-2 family proteins, consisting of three subfamilies: the pro-survival members, such as Bcl-2 or Mcl-1, the pro-apoptotic Bax/Bak subgroup, and the pro-apoptotic Bcl-2 homology 3-only (BH3-only) proteins.
Many cancers overexpress pro-survival members of the Bcl-2 family.
The pro-survival members, BCL-2, BCL-XL, BCL-W, MCL-1 and A1, are essential for cell survival.
Of these, the most highly pro-survival members share multiple BH domains, including Bcl-2, Bcl-xL and Mcl-1.
The Bcl-2 gene family consists of pro-apoptotic and pro-survival members that interact physically and functionally to regulate apoptosis.
Furthermore, SCLC cell lines are sensitive to inhibition of the pro-survival members of the BCL-2 family (Shoemaker et al, 2008; Dean et al, 2011).
ABT-737 is a BH3 mimetic that efficiently antagonizes various pro-survival members of Bcl-2 family and promotes the release of Bax and Bak.
The pro-apoptotic BH3-only proteins inhibit the pro-survival members of the family and are required for initiation of apoptosis signaling.
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