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Vascular endothelial growth factor in breast tumor cytosols is correlated with microvessel density, and VEGF165 content correlates with disease-free and overall survival in primary breast cancers.
Cytoplasmic but not nuclear Skp2 expression was associated with five-year overall and disease-specific survival in primary melanoma patients.
To explore this, we investigated cytosolic PrP biogenesis and effects on cell survival in primary neuronal cultures from different mouse brain regions.
This finding was consistent with the study by Li et al. that high cytoplasmic but not nuclear Skp2 expression predicted worse 10-year overall survival in primary melanoma [13].
Heterologous expression of pilB from NEM316 in L. lactis did not confer any significant advantage for survival in primary activated macrophages, as compared to the control strain (Fig. 3).
In melanoma, Li et al. have shown that gain of Skp2 protein expression are implicated in melanoma progression and Skp2 cytoplasmic expression predicted worse 10-year overall survival in primary melanoma, suggesting that cytoplasmic expression of Skp2 defines a subset of aggressive melanomas [13].
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Figure 3C shows the Kaplan-Meier overall survival and progression free survival curves in primary and metastatic tumors.
Indeed, we recently reported that HIV-1 infection triggers the activation of the PI3K/Akt cell survival pathway in primary human macrophages and renders these cells resistant to cytotoxic insults [5].
Sixty-three papers from their reference list dealt with survival analysis in primary breast cancer.
The aim of this study was to investigate the regulation by CCN2 of cell survival pathways in primary HSC.
A striking finding from our study was the correlation of high PAK1 expression with a better survival outcome in primary pancreatic cancer patients.
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