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Thus, tumour cell lines with constitutive STAT3 phosphorylation and dependent on STAT3 for survival exhibit a strictly STAT3-dependent aerobic glycolytic phenotype, comparable to that observed in the Stat3 C/C MEFs.
We took advantage of engineered Tsc2 +/− Eμ -Myc and Pten +/− Eμ -Myc tumors as these are dependent on Mcl-1 for their survival, exhibit deregulated mTORC1 activity a central regulator of translation initiation, and are genes for which mutations have been documented in human Burkitt's lymphoma.
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The effect of SPA on cell culture survival exhibited a dose response curve best described as a reverse sigmoidal function with an R2 value of 0.96.
Egg-to-adult viability and adult male survival exhibited significant additive genetic variance due to sires, but adult female survival did not (Table 1).
For instance, the decrease of survival among birds older than 4y old during 1986–2007 (a = 0.264, b = 0.241) showed a long-term temporal autocorrelation (i.e., red noise), whereas for birds up to 4y old (a = −0.018, b = 0.250) survival exhibited a short-term temporal autocorrelation (i.e., blue noise).
Survivin has been implicated in aberrant cell survival exhibited by tumorigenic cells [ 24].
However, the progression-free survival exhibited no significant relationships with NLR/GPS.
According to a univariate analysis, the overall survival exhibited a significant relationship with the pretreatment AGR and NLR.
According to a univariate analysis, the progression-free survival exhibited a significant relationship with the pretreatment AGR only.
This revealed that group 1 animals (short survival) exhibited significantly lower body weight than those in group 2 (long survival), with mean (± s.e.m).m
However, the decrease in clonogenic survival exhibited by positive controls, etoposide (100 μg/ml) and vincristine (0.1 μg/ml) was slightly greater.
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