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Although several investigators have examined whether interval cancers are associated with poor survival, controversy remains.
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Any formula for predicting human survival will invite controversy.
Adjuvant systemic chemotherapy in premenopausal patients has been shown to improve survival [ 1], but controversy about the role of chemotherapy in patients with hormone receptor-positive tumors still exists.
Early tracheostomy may improve survival, although its impact remains controversial (a controversy hopefully to be answered by the TracMan study [ 1]).
However, Hallstrom et al. [ 11] reported an association between subsequent shock delivery by emergency medical service (EMS) providers and decreased hospital survival, which has led to controversy.
Background Notwithstanding the negative result of the International Study of Infarct Survival-4 (ISIS-4), the controversy about the role of magnesium in acute myocardial infarction is still open because, according to experimental data, magnesium could decrease myocardial damage and mortality only if infusion is started before reperfusion.
Although intensive follow-up is associated with improved survival, there are still international controversies on how to best organise follow-up of colon cancer patients.
Although many clinicians have investigated the impact of tumor thrombus on survival of patients with RCC, controversies surrounding this issue remain [ 5- 9].
Whether or not open lung strategies improve survival is a subject of ongoing controversy.
This failure of gefitinib to show a survival advantage over placebo resulted in controversy about the registration (Thatcher et al, 2005; Twombly, 2005).
However, there is controversy as to whether the survival benefits of four drug combination regimens outweigh the associated toxicities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com