A key for long-term survival and function of biomaterials is that they do not elicit a detrimental immune response.
In this study, we assessed survival and function of surface-engineered porcine islets genetically modified to overexpress Bcl-2.
The increased TGF-β expression and signaling interferes with PDGF-Rα and VEGF-A signaling hence affecting survival and function of MFBs and ECs.
Thus, we investigated their ability to produce DA in vitro and the survival and function of HAE cells grafted into a rat model of PD.
Accumulating evidence points to several compartments for signaling, several en route destinations for signaling, and the importance for retrograde signaling in regulating the survival and function of neurons.
Besides the indirect effects on the survival and function of T cells through autophagic proteins, autophagy also showed a direct role in antigen presentation to antigen-specific T cells (a process essential for the induction of acquired immunity) [41].
Importantly, the impact of different challenges such as genetic perturbations or exposure to drugs on the survival and function of defined neuronal populations in the C. elegans nervous system can be readily studied in vivo.
Despite the promise for stem cell-based tissue engineering for regenerative therapy, slow and insufficient vascularization of large tissue constructs negatively impacts the survival and function of these transplanted cells.
Encapsulation in semipermeable barriers prolongs the survival and function of islets to different extents depending on the diabetic animal model, but immune suppression may also be needed for long-term graft survival, especially with xenografts.
We demonstrated the importance of cell cell and cell matrix interactions in the survival and function of these cell types, and the capacity to influence encapsulated cell phenotypes through modulation of hydrogel characteristics or gene silencing.
In this study, a TLR1/TLR2 agonist enhanced the survival and function of administered T cells and altered the glioma microenvironment by simultaneously elevating the number of CD8+ positive T cells and down-regulating the number of immunosuppressive myeloid-derived suppressor cells (MDSCs).
