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We applied this method to NF-κB, a family of dimeric transcription factors that plays central roles in immune responses, cell survival and aging, and its dysregulation is linked to many pathological states.
These negative regulatory pathways are critical to prevent the hyperactivation of p53 that can have devastating effects on organismal survival and aging (Campisi, 2005; Liu et al., 2010).
Decreasing HIV seroprevalence among those admitted to jails and prisons, prolonged survival and aging of the US population with HIV/AIDS beyond the crime-prone years, and success with discharge planning programs targeting HIV-infected prisoners could explain the declining concentration of the epidemic among correctional populations.
Age is the primary predictor of chronic illness survival, and aging explains the growth in prevalence of NCDs globally [ 7].
Nucleosome survival during transcription is important for the maintenance of chromatin integrity, gene regulation, cell survival, and aging.
In the present review we describe how sphingolipids, with special emphasis on ceramides and sphingosine-1-phosphate, can act as physiological regulators of autophagy in relation to cellular and organismal growth, survival, and aging.
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Accumulating evidence suggests that autophagy-associated signaling and genes are involved in cell survival, cell death, and aging (Meijer and Codogno, 2009; Vellai, 2009).
They wanted to find out whether polygynous males had lower survival rates and aged faster than those of monogamous species.
We characterized captive survival and age-related traits in F1 and F2 offspring of wild-caught N. furzeri.
Consistent with these reports, our results demonstrated that CR caused activation of Akt/p70S6K1 signaling, indicating these altered signaling pathways conferred a beneficial effect on cell survival and age-delaying through regulation of p16 expression in response to nutrition deficiency.
The analysis considers two explanations for the crossover: selective survival and age misreporting.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com