Combining chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq) allows the accurate survey of interactions between proteins and DNA, enabling the study of epigenetic marks which is essential for a full understanding of transcriptional regulation of genes.
Moreover, a survey of interactions with the mass media among researchers in France, Germany, Japan, the UK, and the US concluded that "the scientists most involved in these interactions tend to be scientifically productive, have leadership roles, and… that they perceive the interactions to have more positive than negative outcomes" [ 119].
Technologies to perform systematic genome-wide surveys of genetic interactions (including SSL) were developed recently by our group (Butland et al., 2008) and by Gross and colleagues (Typas et al., 2008) to elucidate the global pathway architecture of E. coli.
Indeed, a recent survey of protein interactions uncovered a rate of 94% that protein interactions are determined by a single pairwise domain interaction [ 15] while protein interactions that involve interactions between two or more domains are hardly found.
A brief survey of host guest interactions involving dendritic architectures is presented.
A survey of the interactions between phosphorus (P) species and the components of calcareous soils shows that both surface reactions and precipitation take place, especially in the presence of calcite and limestone.
To our knowledge, this is the first study to report upon patterns of supplement use during chemotherapy in relation to recommendations from treating physicians, and the first survey of these interactions between cancer patients and their doctors.
The second signaling network represented a large-scale survey of pathway interactions in response to 231 combinations of 21 different ligands (double ligand screen) carried out by the Alliance for Cellular Signaling (AfCS) in RAW 264.7 macrophages [ 9].
For example, a diary-based survey of close interactions of a sample of the human population in different European countries showed a high degree of age assortativity, i.e. the tendency of individuals of a given age range to interact with other individuals of the same age range (Mossong et al. 2008).
One study of physicians revealed that those surveyed were unaware of interactions involving SJW including: SJW-warfarin (56%), SJW-digoxin (68%), and SJW-OCP (68%) [ 28].
