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Microglia constitute the primary resident immune surveillance cell in the brain and are thought to play a significant role in the pathogenesis of several neurodegenerative disorders, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and HIV-associated dementia.
Dendritic cells (DC) are widely acknowledged as the central surveillance cell type and play an important role in the activation of lymphocyte subsets to control or eliminate human tumors.
None of them were able to follow the expected data reporting standards during the flood period and none of them received any feedback from the district headquarters or the state surveillance cell regarding reporting quality or status.
By linking genome stability surveillance, cell cycle, and energy metabolism, the ~370 kDa Serine (Ser)/Threonine (Thr) kinase ataxia telangiectasia mutated (ATM) has begun to emerge as a central DNA damage checkpoint that connects cellular bioenergetics with cancer predisposition and aging [ 1- 4].
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These are surveillance cells found in all tissues and, as specialised antigen presenting cells, direct immune responses.
Endothelial cells not only provide barrier and endocrine functions but are also essential innate immune surveillance cells.
A slightly different version of the proteasome, termed the immunoproteasome, exists in immune surveillance cells like dendritic cells, and is up-regulated by immune response modulators such as interferon-γ.
P53 is a key regulator of stem cell homeostasis that impacts an array of cellular functions including genomic surveillance, cell-cycle regulation and apoptotic and inflammatory response.
The GPI-linked protein Rae-1, an NKG2D ligand member, is responsible for interacting with immune surveillance cells.
Tumour-associated macrophages found in many solid tumours may be converted into tumour-surveillance cells after blocking this interaction.
Immune surveillance involves cell types in both branches of the immune system: innate [e.g. natural killer (NK) cells] and adaptive [e.g. CD8+ cytotoxic T-lymphocytes (CTLs), CD4+ T-helper cells] [ 19, 20].
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