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Figure 1 shows that a number of markers have large column sums, both in the region surrounding probe RP11-393K10 and elsewhere in the genome.
We have also documented here a surprising rebound of TH labeling in the tissue surrounding probe tracks by 24 h postimplantation: this might indicate the presence of surviving DA terminals, which justifies our efforts to protect and preserve their neurochemical activity.
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We suspected that this bias might be due to a little bleed over from the surrounding probes on the array.
Note that signals obtained with these probes and the surrounding probes were routinely excluded from all results shown above as mentioned.
Irregular GC content, either at the probe level and/or within regions surrounding probes, is highly correlated with genomic waves in signal intensity induced by DNA quantity (69) (Supplementary Material, Fig. S6).
For sufficient sample sizes, we describe further below an approach to correct the bias by comparing intensities of individual probes using data from surrounding probes (via segmentation), without the need to model or otherwise consider the sequence context.
There are, for example, "technical" factors associated with the correction for background fluorescence owing to bleed over-effects from surrounding probes on the arrays [ 32], or to spatial artefacts [ 33, 34].
Two samples (6 and 22) had compound heterozygous changes in ATP8B1 detected by FS but not by MR. Both samples had two variants in close proximity; therefore we speculate that these are in cis and that each sequence variant has impaired the hybridisation of surrounding probes.
It has been well known that c(f) becomes minimum at the upper hybrid resonance (UHR) frequency (fUHR) without depending on an angle between the probe and the magnetic field and a sheath surrounding the probe when plasma is assumed to be collisionless (e.g., Balmain, 1964; Oya and Obayashi, 1966; Suzuki et al., 2010, this issue).
In actual situations, for evaluating the probe impedance it is essential to consider the effect of an ion sheath surrounding the probe.
The agreement came in a face-to-face discussion of the controversy surrounding the probe between David Cameron and military ruler General Prayuth Chan-ocha at a summit in Milan.
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