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The lesion itself and the surrounding marrow may enhance with gadolinium [2].
A hypointense or isointense signal was associated with benign edema, whereas tumor showed hyperintensity in contrast to normal surrounding marrow.
We considered that the shorter particle path length of In compared to Lu may have provided better targeting of small bony lesions whilst limiting potential toxicity to the surrounding marrow.
In the scaffolds cultured in control medium, or osteogenic medium or in scaffolds switched to osteogenic medium for 1 week, mineralised tissue was observed both histologically and by μCT, but this lacked any significant structural organisation or surrounding marrow.
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It is important to recognize the linear, low signal intensity fracture line on MRI since surrounding bone marrow edema may simulate marrow replacing tumor.
The regions of marrow edema also showed patchy low signal (lower than surrounding fatty marrow, but higher than adjacent muscle) on T1-weighted images.
The bone and muscle surrounding the marrow appear to protect the cells.. It's unclear how long patients will need to wear the device.
Surrounding bone marrow and soft tissue oedema are frequently observed.
Most bone tumours will be evident as lesions with low signal against a background of surrounding fatty marrow [4].
a. Axial T2 WI fat saturated MR image shows a focal bony defect with surrounding bone marrow edema at the superolateral aspect of the patella.
Two patients demonstrated focal 18F-FLT avid lesions with a tracer uptake higher than that of the surrounding bone marrow (Fig. 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com