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The cytokeratin-18 neoantigen (M30), reflecting ongoing hepatocyte apoptosis, is elevated in patients with chronic hepatitis C. The M30 may be a surrogate to replace the repeated liver biopsy.
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In prison, Jessica has found surrogate mothers to replace the real one who has yet to visit her incarcerated daughter.
The algorithm relies on the construction of surrogate models to replace the original model within the region of interest.
Will the use of a potential surrogate endpoint to replace the unobserved true endpoint give qualitatively the correct results?
With cancer patients now living longer and receiving more complex neoadjuvant therapies, there is a growing need to develop imaging methods to act as surrogate endpoints to replace the more traditional endpoints of morbidity or mortality.
28 If this gold standard is considered too complex or too expensive to manage, physicians should review possible surrogate variables to replace the ones used in the gold standard.
Since it is challenging to visualize multiphase flow processes occurring at high pressure conditions at the meter scale, a testing method was developed based on the use of surrogate test fluids to replace the scCO2 and formation saline water.
Further, validation of a biomarker as a robust surrogate end point to replace overall survival would also potentially speed up the drug development pathway.
In particular, we were not provided with data on CO2, NO, or NO2 other than in the years 1998 2001, which prevented us from studying the suitability of any of these emission constituents as alternative surrogates for diesel to replace CO.
To improve the computation efficiency, surrogate models are used to replace expensive simulations of engineering problems.
Consequently we build a surrogate model in order to replace it.
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