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Unlike the in vivo assay, the in vitro binding activity is used as a surrogate method to analyze the mAb candidates.
Sparing laborious nebulization tests, this study aimed to demonstrate the feasibility of a high throughput, material saving surrogate method to predict protein stability after nebulization.
The activated sludge FM-BOD assay presented here is an exceptional surrogate method to the standard BOD5 assay, providing representative, same-day BOD analysis of WWTP samples with a comparable detection limit, a 4-fold greater analytical range and much faster analysis time.
The goal was to evaluate whether any IVIVC observed would be evident even under conditions of heat exposure, in order to investigate further whether IVPT may have the potential to serve as a possible surrogate method to evaluate the in vivo effects of heat on the bioavailability of a drug delivered from a TDS.
HOMA-IR is a robust surrogate method to estimate IR in epidemiologic or clinical setting.
Second, we used an in vitro tumoursphere assay, a powerful surrogate method to evaluate cancer stem/progenitor cells (Ponti et al, 2005).
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Shortly thereafter, clinicians sought surrogate methods to predict survival outcome.
The CGS method may be an improvement over existing surrogate methods to detect genes of foreign origin.
Nevertheless, radiographic JSN is a surrogate method used to assess knee cartilage, [ 18] and has been regarded as insensitive to change.
Since the sterilising activity of new antituberculosis drugs is difficult to assess by conventional phase III studies, surrogate methods related to eventual relapse rates are required.
Given the subnetwork a surrogate method is applied to solve the Traffic Signal Synchronization problem.
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