Sentence examples for surrogate endpoints from inspiring English sources

Many medicines are approved on the basis of what scientists call surrogate endpoints, like proof that they lower cholesterol, rather than because they have been shown to reduce the risk of death or disease.

Besides, 45 (40%) primary outcomes were surrogate endpoints.

Surrogate endpoints may occur more frequently than their standard counterparts.

These anatomical biomarkers are the only imaging surrogate endpoints that are accepted in cancer treatment.

To provide multi-centre validation and qualification of pharmacodynamic imaging biomarkers and surrogate endpoints.

The validation requirements are much higher for surrogate endpoints than for pharmacodynamic biomarkers.

Methodological requirements differed mainly in the acceptance of low-level evidence, surrogate endpoints, and data modeling.

Outcome measures can be either final (clinical) endpoints or intermediate (surrogate) endpoints.

Very important is the increasing use of (imaging) biomarkers as surrogate endpoints for clinical trials.

In our systematic review, we found that 40% of primary outcomes were surrogate endpoints.

Surrogate endpoints are also accepted more readily, if they are reasonably likely to predict clinical benefit.