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These trials have used surrogate end points as the primary outcomes of interest.
Furthermore, the use of surrogate end points in SCLC has not been explored.
These efficacy trials are using surrogate end points in an innovative Phase 2B trial design.
The rationale for using IVUS-based surrogate end points in clinical trials is discussed in the present review.
However, it is not clear which potential surrogate end points are reliable and valid for studying pulmonary arterial hypertension.
Clinical trials often rely on echocardiographic measures of left ventricular size and function as surrogate end points.
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They concluded that surrogate end-points with such low response rates lack robustness.
DFS is seen both as a surrogate end-point and as an end-point in itself in clinical trials.
Consequently, MRD negativity has the potential to soon become a regulatory surrogate end-point for drug approval.
Multi-dimensional image analysis is being used increasingly to arrive at surrogate end-points for drug development trials.
RECIST is a surrogate end-point.
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