Blood leucocytes and platelets are exposed to many soluble circulatory factors associated with metabolic stress and are, therefore, an ideal surrogate for determination of BHI in patients.
The potential for adopting the relatively simple-to-conduct edge bearing test as a surrogate for direct determination of the critical transverse material properties is investigated.
This source is also used for both the national and international press, TV, and radio stories, and thus provides an ideal surrogate for the determination of overall media impact.
The recoveries of surrogate standards for PCB determinations were in ranges of 82 105%.
The aim of this work was to develop and validate a sensitive ion-chromatography based analytical procedure for the determination of surrogate powders collected on filter samples so as to meet analytical requirements set out in this ISPE guide.
Taken together, these results qualify this novel approach as a suitable surrogate assay for the determination of herpesvirus neutralization.
Rb+ was used as a surrogate tracer for the determination of K+ uptake by bacteria.
Because EGFRvIII mutation is associated with genomic deletion of exons 2 7, we sought to determine whether assessment of this deletion by DNA copy number data could serve as a surrogate for RNA-based determination.
We investigated whether mRNA levels of E2F1, a key transcription factor involved in proliferation, differentiation and apoptosis, could be used as a surrogate marker for the determination of breast cancer outcome.
Studies have shown that tumour growth rate is a valuable parameter for, for example, prediction of recurrence after surgery (Cucchetti et al, 2005) and survival of patients (Blankenberg et al, 1995), and the change in tumour growth rate can serve as a surrogate end point for determination of therapy response (Haney et al, 2001).
