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ICUSTAY_ID and SUBJECT_ID identify the ICU stay and the patient; DOB and DOD are surrogate dates of birth and death; see text for discussion.
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The use of such surrogates dates virtually from the Islamic Revolution in 1979; American officials believe Iran was behind the bombings of the United States Embassy and Marine barracks in Lebanon in 1983 and the strike against Air Force personnel at Khobar, Saudi Arabia, in 1996.
Specimen collection date was used as a surrogate for date of diagnosis (typically the same date for rapid influenza testing and DFA) or, if not available, the report date.
Date of publication was chosen as a surrogate for date of diagnosis of relapse as it was the only consistent date available for all the published studies (see Table 2).
While missing onset data can have serious clinical implications in stroke management, our results suggest that using date and time of presentation to ED from an administrative database as a surrogate for date of stroke onset should not lead to a strong exposure misclassification effect on risk estimates obtained from case-crossover studies.
Yet none of these factors was taken into consideration in the only meta-analysis applied to environmental surrogates to date [55].
Currently the only available surrogate for the date of BO onset is the date of BO diagnosis.
Date of self-report was used as a surrogate for the date of diagnosis.
To date, surrogate markers for estimating Aβ42 generation in the brain have not been identified.
For adjuvant trials, the use of disease-free survival (DFS) is an accepted surrogate because, to date, mature follow up of both individual trials and their meta-analyses have consistently confirmed that improvements in DFS subsequently translate into firm improvements in OS.
A possible limitation is that we used the date that a publication was first added to PubMed as a surrogate for the publication date because the actual date of journal publication is difficult to determine.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com