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The diluting effect of the large surrogate compartment of the interstitial space for the tumor is accounted for.
In our patients we have not been able to measure these parameters in muscle tissue, however erythrocyte levels can be taken as a surrogate compartment [ 59].
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However, in both cases, correlations were relatively weak, which may reflect the heterogeneity of the patient population or the limitations of using the peripheral blood compartment as a surrogate for inflammatory reactions of the skin or muscle.
The knee adduction moment is recognized as a surrogate measure of the medial tibio-femoral compartment joint load and therefore represents a valid intervention target.
High-volume production (surrogate for occurrence quantity) Persistence in a compartment with likelihood of exposure Bioavailability and bioaccumulation Toxicity Localized accumulation with likelihood of exposure.
Microfluidic channels interconnecting the compartments permit compounds contained in "blood surrogate" culture medium, to re-circulate through and past the respective cell chambers, emulating the circulatory system of a living animal.
Lung weights, collagen and total protein in BALF, as surrogate endpoints of extravasated capillary fluid into the alveolar compartment accessible by BAL fluid, followed a similar trend (Fig. 3).
Alternatively, one may look for and use valid surrogate tissues or surrogate cells of the true effects compartments.
Thus, because short leukocyte TL might be a surrogate marker of senescence in the bone marrow stem cell compartment, our results might also reflect a more general relationship between hostility and organismal aging.
Pearson et al. [25] developed emissions factors for the main logging compartments to be multiplied to extracted volumes, as a surrogate for carbon emissions from selective logging.
Moreover, this miRNA (and possibly others) might not only reflect peripheral pathophysiological mechanisms leading to neurodegeneration but could also be a basis for biomarker development in the future as specific molecular markers could turn out to be useful surrogate parameters for disease, even if a correlation between the CSF and serum compartments is not observed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com