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While wild-type FMRP was localized predominantly in the cytoplasm as expected, the patient FMRP showed a surprising localization pattern that was not observed with the wild-type protein (Fig 2A).
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The so-called Localized Waves (LW), and the "Frozen Waves" (FW), have raised significant attention in the areas of Optics and Ultrasound, because of their surprising energy localization properties.
The distinct roles for SUV39H and SUV420H proteins are somewhat surprising given localization to PCH by the latter is dependent on H3K9me3 catalyzed by the former [10].
This localization is surprising as histones are considered to be amongst the most conserved proteins in eukaryotic cells and their role is linked with the chromatin structure.
Mitochondrial localization is surprising in light of a previous report demonstrating interaction between UBIAD1 (also known as TERE1) and apolipoprotein E [21], [22].
This is particularly surprising given that most localization to granules is associated with translation repression.
It is surprising that Orai3 lacks localization to the plasma membrane in endothelial cells under basal conditions.
In particular, it isn't clear why the authors find it so surprising that RNAs change localization status in different cell types and at different times.
The absence of γH2AX immune localization was surprising, for it is hardly conceivable a genome-wide protaminization without torsional stress alleviation through DNA double-strand breaks (Laberge and Boissonneault, 2005).
This latter result is not surprising given the differing intrinsic localization of KChIP2 compared with KChIP1.
This localization is not surprising, as the hydrophobic region of GPI-SPs can potentially function as an ER-signal sequence, explaining why cFRGPI-SP localizes to the ER.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com