We developed a practical and safe pedicled flap for reconstruction of ischial pressure sores based on the rich available perforators from the internal pudendal artery and the surplus of skin at the infragluteal fold.
Surplus, normal, skin was obtained as previously described from three donors following surgery according to protocols approved by the Ethics Committee at Lund University.
Total elasticity (Ua/ Uf) was significantly reduced in all tested areas except the zygomatic, especially in T2, and this reflects a higher impact of the water surplus on skin extensibility (Table 3) rather than in the elastic recovery (Ua).
Approximately 2 L of water were added to the daily diet of Group 2 individuals for 1 month to quantify the impact of this surplus in their skin physiology.
Surplus healthy Caucasian skin containing hairs were selected for the study, from patients between 18 and 60 years of age who had been operated in the plastic surgery department at the Valencia General Hospital and who voluntarily accepted their inclusion in the study.
Volunteers were then asked to supplement their normal diet with a fixed daily amount of water for 4 weeks in order to establish the impact of this surplus on their normal skin physiology.
At fixed times of 0.5, 2 and 4 h after application, the surplus sample was removed from the skin surface, the skin surface was washed three times with PBS and dried gently under cold air with an electric hairdrier.
At a fixed time after application, surplus sample was removed from the skin surface, and the skin surface was washed three times with PBS and dried gently under cold wind with an electric hair drier.
In any case, further studies are needed to establish possible penetration enhancement effects in vivo by CMS for typical anti-inflammatory drugs and a potential therapeutic surplus value, both on healthy and barrier-altered skin.
Current account in surplus.
