The patient recovered well from surgery and was referred for oncological follow up and post- surgical chemotherapy (same regime as NAC).
Clinical and pathological variables (FIGO stage, grade, age, menopausal status, optimal surgical debulking, chemotherapy regime, pre-operative CA 125 levels), gene expression (VEGF, p53 and p21Wap/Cif1) and EDD expression were correlated to patient outcome using comprehensive clinical follow-up data for each patient.
A standardised surgical protocol and antibiotic regime based on guidance from our local microbiology department were followed.
The advent of Parecoxib, a selective COX-2 inhibitor that can be administered parenterally, made the use of NSAIDs as part of a multimodal pain therapy regime in surgical patients more feasible.
With the exception of cystic mesotheliomas, primary malignancies of the peritoneum have very poor prognosis despite aggressive surgical and multiagent chemotherapy regimes; the median survival reported is 12 25 months.
Also, the induction of apoptosis plays a pivotal role in non-surgical cancer treatment regimes such as irradiation, chemotherapy, or hormones.
Compared to the classical double transplant kidney pancreas, this new protocol presents several advantages, concerning to the nature of the implant, immunosuppressive drug regime and the surgical procedure itself.
Advantages in surgical techniques, radiation therapy techniques, chemotherapeutic regimes, and different combined-modality approaches have yielded only a modest impact on the prognosis of patients with pancreatic cancer.
With better surgical techniques and more effective immunosuppressive regimes and medical management, recipients are surviving longer [ 12] and patients are being transplanted at an older age.
However, conservative regimes would yield to surgical approaches for patients predisposed to bone destruction, sequestrum formation, paraspinal abscess and nerve compression.
