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Rather the E3 and E2 components bind to topologically unique nucleosome surfaces distant from the site of catalysis to position the E2 active site directly over the H2A C-terminal tail near the target lysine.
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Conversely, above the steel surface distant from the zinc layer, the surface concentration of Zn2+ was almost zero during galvanic corrosion.
As the surface was approached, the pH over the zinc layer decreased slightly from ca. 5.6 in the original bulk solution, while the pH over the steel surface distant from the zinc layer increased to ca. 11.5.
As a result of these studies, we show how subtle differences in residues at a surface distant from the functional site code for a conformational switch that allows the a1 homeodomain to become active in DNA binding in association with its cofactor α2.
However, similar interaction energies were also observed for other locations on the protein's surface, distant from the co-activator binding site.
However, when SA was docked at other locations on the protein surface, distant from the co-activator binding site, the interaction energy turned out to be similar or even more favorable (data not shown).
In contrast, the endosteal surface distant from bone erosions contained only few bone cells.
Similarly, no bone cells were seen at the endosteal bone surface distant from bone erosions.
Second, the C1B domain docks to the kinase domain surface distant from the active site, yielding allosteric inhibition.
The relatively large size of SBL1 was an advantage here because most of the surface is distant from the active site.
Although cross reactivity between fungal proteins with homology levels between 40 and 70% is well reported there are other examples in the literature such as the birch tree allergen Bet v 1 and its hypoallergenic isoform Bet v1 l which show that single amino acid changes or differences at surface residues distant from the epitope may significantly reduce reactivity [ 60- 62].
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