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Most importantly, addition of Wnt3a proteins to cultured Rab8a −/− MEFs markedly stimulated cell surface Lrp6 phosphorylation (Ser1490) to a level equivalent to that of Rab8a +/+ cells (Fig. 2F), suggesting that Rab8a −/− cells can properly respond to exogenous ligand stimulation by assembling an Lrp6-containing surface protein complex (Bilic et al., 2007).
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BLP2 may also be a component of surface protein complexes involved in biofilm formation.
We present bioinformatics and experimental evidence that the encoded proteins are functionally coupled and possibly form a cell-surface protein complex that could play a role in sugar metabolism.
Based on the experimental evidence and predictions provided above that the CscA, CscpB, CscC and CscD proteins are functionally coupled, we propose that they form a cell-surface protein complex.
Hence, the presence of ConA-like domains in CscC proteins would support a role of the proposed Csc cell-surface protein complex in binding and/or degradation of complex (plant-derived) oligo- or poly-saccharides.
We have presented bioinformatics and experimental evidence that the extracellular CscA, CscB, CscC and CscD proteins are functionally coupled and possibly form a cell-surface protein complex that could play a role in sugar acquisition.
Structural information on merozoite surface proteins complexed to antibodies provides crucial information for knowledge-based vaccine design.
From the 10 million they identified six small-molecule, HIV-surface protein complexes that display unique modes of binding.
Additionally, it has been proposed that the cscABCD genes in L. plantarum encode cell-surface protein complexes involved in the degradation and utilization of complex plant polysaccharides [ 52].
We propose that the CscA, CscB, CscC and CscD proteins form cell-surface protein complexes and play a role in carbon source acquisition.
Apart from the proposed glycoprotein sex pheromones in harpacticoid copepods, Tigriopus japonicus [18], only the partially surface-bound protein complex cues that control the gregarious larval settlement in barnacles, Balanus amphitrite, have been characterized successfully [28].
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