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Here we report the solution structure of the Apaf-1 CARD domain and its surface of interaction with caspase-9 CARD.
A supercell of 4 × 4 graphene (12.30 × 12.30 × 16 Å) (left side of Fig. 1) has been used as surface of interaction.
We have therefore identified three mutations directed against the residues from the acidic ridge of frataxin (E108K, E111K and D124K) and two surface-exposed mutations (W155R and N146K) that specifically disrupted the interaction of frataxin with the core complex, defining a surface of interaction on one side of frataxin, spreading from the acidic ridge to the β4-sheet (Fig 3D).
Epithelial cells of mucosa also cover each centimeter of the digestive tract, the other surface of interaction with the environment.
The signal from Psf2 was consistently stronger than from Psf1 and displayed a wider surface of interaction with chromatin.
A summary of the interface characteristics (surface of interaction, energy, hydrogen bonds and salt bridges) for each model is provided in Table 1.
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Interfaces, defined as the surface of interactions between two parts of a system at a discontinuity, are very widely found in nature.
The domain swapped AAK dimer shows surfaces of interaction in the C-lobes that one assumes are important for intermolecular autophosphorylation if the authors' model is correct.
Because of the large surface area of interaction of the drug-immunophilin complex with calcineurin, FK506 and CsA have a specificity for their biologic targets that is equivalent to growth factor-receptor interactions.
Moreover, the relatively low surface area of interaction of the peripheral subunits was found to correlate with their propensity to dissociate.
The difference in binding angle does not significantly change the surface area of interaction, or the angle of the key kinase regulatory element helix αC.
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