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This selective stimulation of synaptic NMDARs induces LTP of AMPAR-mediated miniature excitatory postsynaptic currents (mEPSCs) and is accompanied by a rapid surface insertion of AMPARs into synaptic sites.
The phosphorylation on Ser831-GluA1 is thought to affect plasticity by increasing the AMPAR channel conductance [17] and potentiating GluA1-mediated current [18], [19], whereas the phosphorylation of Ser845-GluA1 accompaniesurfacece insertion of AMPARs receptors at in extra synaptic sites, which provides a pool of receptors available for LTP induction [20], [21].
Many AMPAR-interacting proteins that control surface insertion of AMPARs have been identified, such as postsynaptic density-95 (PSD-95), glutamate receptor interacting protein (GRIP /AMPA receptor binding protein (ABP), PICK1, 4.1N and the A-kinase anchoring protein 79/150 (AKAP79/150).
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Recent work implicates endosomes as a source of new membrane lipids for structural spine expansion [11], in addition to providing a supply of AMPARs for surface insertion during LTP [2].
Moreover, endosomes appear to translocate from the dendritic shaft into the spine during LTP, possibly providing a supply of AMPARs for surface insertion and new membrane for spine expansion during plasticity [10], [11].
Fan et al. (2012) utilized type I and type II cohesin dockerin interactions to construct minicellulosomes and mediate the anchoring of cellulosomes onto the cell surface, respectively, which allowed the complete regulation of cellulosome assembly, their attachment to cell surface and insertion of catalytic units.
The extent of disorder in the hydrogenated segment may be controlled by varying the size of the fluorinated segment, and this could be exploited for designing functionalized surfaces with insertion of other molecules in the defect region.
When the surface gets oxidized due to residual water in the electrolyte, oxidation of the SiH groups at the (111) surface involves fast insertion of oxygen atoms into all three silicon backbonds.
"Segond fracture:" an avulsed bone fragment of the proximal tibial condyle, below the articular surface at the insertion of LCL.
The compact lamellar bone offers a good surface for the insertion of the osteosynthesis screws, while the cancellous part of the graft provides a wider interface between donor and recipient bone, allowing early revascularization.
Earlier studies have indicated that spreading of macrophages on human IgG-coated surfaces involves the insertion of membrane from intra-cellular source and is dependent upon PtdIns 3-kinase [36].
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