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Our study demonstrated that miR-33a plays a tumor suppressor role in breast cancer metastasis.
These studies strongly suggest that connexins and GJC serve a tumor suppressor role.
Together, these data support a conserved tumor suppressor role for Hippo signaling in mouse models of human tumorigenesis.
The authors therefore suggest that BMP4 is playing a tumor suppressor role in LSCC, while SOX2 repression of BMP4 transcription causes cell growth [64].
These data suggest that JNK may have a tumor suppressor role in breast cancer.
These data are consistent with a possible tumor suppressor role of TMEFF2 in these tissues.
These findings point to a tumor suppressor role for miR-34c in high grade serous carcinomas.
Moreover, SOX9 has shown a tumorigenicity inhibitor effect in different tumour cells, suggesting a potential tumour suppressor role [26], [27].
Interestingly, a similar tumor suppressor role for VILIP-1 has been reported recently in two other tumor cell types.
Conversely, reduced expression has been associated with aggressive disease suggesting a potential tumor suppressor role for E2F [26], [26].
Thus, its possible tumor suppressor role needs further investigation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com