Sentence examples for suppressor of its from inspiring English sources
On the other hand, while the C1 domain of RasGRP3 alone showed partial plasma membrane translocation, truncated RasGRP3 constructs, which contain the PT domain and are missing the REM, showed stronger translocation, indicating that the REM of RasGRP3 was a suppressor of its membrane interaction.
Two paralogous TFs having similar DNA binding domains but with different interaction domains may result in one TF acting as a suppressor of its paralog by interfering with the sibling's binding; for example, Foxo1 and Foxa2 have highly similar DNA binding specificities but Foxo1 acts as a suppressor of Foxa2-mediated regulation of Pdx1 in pancreatic β-cells[15].
Accordingly, nearly all females and males recently collected in South East Asia and Samoa are infected with wBol1, and also carry the suppressor of its male-killing activity.
Thus AMPK has a cytostatic effect on proliferating cells, suggesting that it might exert some of the tumour suppressor effects of its upstream kinase, LKB1.
miR-126 is a tumor suppressor, because of its antioncogenic properties.
Then, we focused on the p53 tumour suppressor because of its widely demonstrated role in cancer.
In contrast, p42 is considered to be a potent tumor suppressor because of its inhibitory growth function.
STAT1 has been described as a tumor suppressor because of its function as a mediator of IFN-γ - dependent immunosurveillance [ 1].
Recent evidence have described that, although p53 is a tumor suppressor, some of its downstream targets do not have a tumor-suppressive function.
Mechanistically, these data linked the well-studied DDR signalling pathway and known tumour suppressor functions of its components, including activation of checkpoints and p53-mediated apoptosis and senescence, to an oncogene-induced replicative stress.
PICT1 (also known as GLTSCR2) was considered to be a tumour suppressor because of its localisation at 19q13 (a region that is frequently deleted in human malignant tumours) and its ability to stabilise PTEN (Okahara et al, 2004; Okahara et al, 2006; Yim et al, 2007).
