Sentence examples for suppressive to from inspiring English sources

Although less is known about genes and factors suppressive to Pythium, pathogen genomics and biological control studies are providing useful leads to effectors and antifungal factors.

The term regulatory monocytes is not precisely defined yet, but among the first monocytic cells described to be suppressive to T cells were the so-called monocytic myeloid-derived suppressor cells (mo-MDSCs).

Furthermore, exogenous TGFβ was still suppressive to Ncf1-deficient Teffs.

Functional studies showed that both miR-143 and miR-145 are suppressive to cell growth.

Therefore, we probed whether CuNG could modulate the functional behavior of TAMs from suppressive to proimmunogenic type so that protective Th1 response can be elicited.

CDK4/cyclin D complexes and other Ras-related kinases modulate the phosphorylation of SMAD3 [30], [31], [31], and this modulation of SMAD3 causes its downstream signaling to change from tumor suppressive to oncogenic [29], [30].

The player could order the crew to provide suppressive fire, to maneuver or to beam out, for example, and would then watch the scene play out.

The switch in TGFβ responses from growth-suppressive to EMT-inducing involves a change from Smad-dependent to Smad-independent signaling [24] and appears to be a critical marker of progression in HPV-mediated HNC and EMT.

A previous study showed that loss of Smad4 expression in PDA can lead to the aberrant activation of STAT3, which may contribute to the switch in function of TGFβ from a tumor-suppressive to a tumor-promoting EMT pathway in PDA [20].

We hypothesize that mEHT is an ideal approach for changing the TME from immune-suppressive to immune-stimulatory.

As TGF-β signaling is known to switch from tumor-suppressive to tumor-promotional during cancer progression [ 45], perhaps the difference in the transformed state of the cells is responsible for the opposite effects observed with miR-155 expression.