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An example of suppressive regulation involves a signal peptide in Bacillus subtilis that suppresses the transfer of the integrative and conjugative element ICE Bs1 by responding to environmental changes (Auchtung et al. 2005).
Our previous results [ 8] and those of other workers [ 12] suggest a novel mechanism of tumor suppressive regulation by TGF-β, and implicate RhoB as a negative regulator of TGF-β signal transduction.
Relative to the mechanism of IS transposition, both inducive and suppressive regulation are known.
Collectively, these data thus suggest that antigen uptake following ablation does only lead to enhanced numbers of activated tumour-specific T cells, when suppressive regulation is switched off.
In fact, Inoue et al (2000) demonstrated that 15d-PGJ2 suppressed COX-2 promoter activity by interfering with the NF κB signalling pathway, and that transfection of a PPAR γ expression vector into the endothelial cells resumes the suppressive regulation of COX-2 gene by 15d-PGJ2.
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Whether or not Yap activity is subject to a similar tumor-suppressive regulation is currently unclear.
These findings are in agreement with increased employment of suppressive emotion regulation strategies by the alexithymic group.
Individuals scoring high on the cognitive component of alexithymia are more prone to suppressive emotion regulation strategies rather than reappraisal strategies.
The severity of FNS varied with alexithymia (r = 0.49, p < 0.001) and suppressive emotion regulation style (r = 0.3, p < 0.05).
Alexithymia and suppressive emotion regulation style were stronger in patients than HC, and alexithymia varied with FNS severity.
Patients reported higher alexithymia (TAS-26) and more suppressive emotion regulation style than HC (ERQs; Table 2).
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