Sentence examples for suppressive machinery from inspiring English sources

Similarly, phosphodiesterase-5 inhibitors delay tumor progression by decreasing Arg1 and iNOS expression and by regulating the suppressive machinery of MDSCs [ 40].

Besides Beclin1, many other components of autophagy machinery also play tumor-suppressive roles in tumorigenesis.

Many other autophagy machinery components besides Beclin1 play tumor-suppressive roles in tumorigenesis.

Further experiments using Treg-specific deletion of Dicer or Drosha demonstrated that these knockout mice succumbed to autoimmunity in a manner indistinguishable from Foxp3-deficient mice, indicating a requirement for functional miRNA machinery in Treg homeostasis as well as in suppressive function [11][12][13].

It is well known that the expression of oncogenes, such as Ras or Myc, elicits the cell suicide machinery, a mechanism today widely accepted as an innate tumor-suppressive program.

Tumour cells that have accumulated mutations to circumvent the suppressive effect of TGFβ may not only withstand a TGFβ-rich microenvironment but also exploit the TGFβ signalling machinery for malignant progression [ 1].

On the other hand, tumor suppressive miRNAs, such as let-7 and miR-15 families, downregulate a wide spectrum of positive regulators of the cell cycle machinery [ 55].

Machinery malfunctioned.

His machinery is decrepit.

Machinery wears out.

There as machinery.