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Suppressive function was determined as the ability of Treg to suppress proliferation of Teff.
Suppressive function of Tregs was assessed by using an optimized autologous suppression assay [23], [24].
Both 4-1BB (CD287) and costimulationatinduceduced strong suppressive function of genetically modified Tregs.
We therefore tested whether p38 inhibition may inhibit the suppressive function of nTreg.
More importantly, the ex vivo suppressive function of Treg from AAV patients was defective.
Suppressive function was correlated with CD69 surface expression and TGFβ secretion/expression.
Dysregulation of JMJD2 thus may counteract the tumor suppressive function of Suv39H1.
Additionally, FOXP3 demethylation was positively associated with the suppressive function of Tregs on effector cell division.
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However, the tumour-suppressive function of p53 is closely linked to its ability to induce apoptosis.
The deubiquitinating activity of CYLD for IKKγ is critical for its cylindromatosis-suppressive function [10].
Many studies have indicated that autophagy has a tumor-suppressive function.
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