Sentence examples for suppressive elements from inspiring English sources

Especially, new drugs (i.e. Ipilimumab) have demonstrated that targeting suppressive elements leads to highly improved clinical outcome.

It has become clear that immune escape mechanisms and immune suppression are major obstacles to successful cancer treatment and the combination of cancer vaccination with targeting of the immune suppressive elements holds great promise to future cancer treatment.

This tumour develops in the prenatal phase from ectodermal origin (Coze et al, 1995; Prigione et al, 2004; Wolfl et al, 2005), and is therefore actively shielded by suppressive elements of innate immunity.

INH-ODN 4084-F is the shortest active 12-mer INH-ODN that contains both previously identified suppressive elements (CCT and GGG), appropriately spaced from each other (four nucleotides apart) and properly oriented in a single-stranded ODN molecule (5'-CCT → GGG-3') [ 39].

There are several theoretical advantages of providing immunotherapy in a post-surgical setting; the post-surgical environment is altered due to the presence of wound-healing inflammatory mediators, while cytoreduction removes tumor suppressive elements [ 15] and leads to smaller tumors which are generally more susceptible to immunotherapy [ 16, 17].

In that instance it was originally thought that the deletion removed a gonad-specific suppressive element, but subsequent studies showed that the inserted material was capable of driving Sox9 expression in the mouse gonad [51].

Since restoration of normal GJIC appears to work as tumor suppressive element, GJIC is being exploited as end point for identification of cancer chemopreventive agents [ 28].

On the basis of previous observations that FXR is able to act as a tumor suppressive element in hepatocellular carcinoma and breast cancer, the group investigated to which extent FXR expression is influenced by aberrantly expressed miRNA molecules.

In addition, suppressive DNA elements may modulate the stimulatory effects of CpG DNA.

Thus, the ratio of stimulatory and suppressive sequence elements may determine the immunomodulatory potential of self DNA.

This would imply that human DNA has a high number of suppressive sequence elements that neutralize a small number of unmethylated CpG motifs, representing a mechanism to discriminate self DNA from bacterial DNA via TLR9.