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These Tregs possess potent suppressive activity and are capable of suppressing acute liver allograft rejection.
TSLP directly and selectively impaired IL-10 production of Treg and inhibited their suppressive activity.
A splice variant of AIMP2, AIMP2-DX2, compromises the tumour suppressive activity of AIMP2 and can induce tumorigenesis.
In contrast, KG1.ILT4delta lost the suppressive activity of untruncated ILT4.
De Santo, C. et al. Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat.
Iype, T., Sankarshanan, M., Mauldin, I.S., Mullins, D.W. & Lorenz, U. The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
In a mouse renal cancer model, entinostat has been shown to have suppressive activity for regulatory T cell function, which will be beneficial for eliminating HIV latency48.
All 8 male partners evaluated showed CD8 cell-related cytotoxic HIV suppressive activity.
Those subsets bear IDO and arginase activities and exert a suppressive activity on T-cell proliferation.
Much of this virus suppressive activity has been ascribed to CD8T-cell-directed cytolysis of infected CD4T cells.
The suppressive activity of cHS4 is therefore promoter specific.
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